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Amazon A-F Topical 2 fl. oz.
A powerful formula of 8 rainforest botanicals which are used by the shamans and herbal healers in South America for the skin. This synergistic combination of plants is also available in capsule formula for internal use. This exclusive and proprietary formula contains: jatobá bark, sangre de grado resin, pau d’arco bark, copaiba resin, Brazilian peppertree bark, clavillia herb, anamu herb, fedegoso leaf, distilled water and alcohol.
Each rainforest botanical in this professional formula has been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesing methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants.
Please note that this is a professional product offered by health practitioners and it is not available in retail stores.
Documentation and Research*
This formulated product has not been the subject of any clinical research. A partial listing of published research on each herbal ingredient in the formula is shown below. Please refer to rain-tree.com for their excellent plant database.
Jatobá (Hymenaea courbaril)
Jatobá contains terpene and phenolic chemicals which are responsible for protecting the tree from fungi and mold in the rainforest. In fact, the jatobá tree is one of the few trees in the rainforest that sports a completely clean trunk bark, without any of the usual mold and fungus found on many other trees in this wet and humid environment. These antifungal terpenes and phenolics have been documented in several studies over the years and the antifungal activity of jatobá is attributed to these chemicals.
Yang, D., et al. “Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.” Mycopathologia 1999; 148(2): 79–82.
Rouquayrol, M. Z., et. al. “Antifungal activity of essential oils from Northeastern Brazilian plants.” Rev. Brasil Pesq. Med. Biol. 1980;13: 135-143.
Arrhenius, S.P., et.al. “Inhibitory effects of Hymenaea and Copaifera leaf resins on the leaf fungus, Pestalotia subcuticulari.” Biochem. Syst. Ecol. 1983; 11(4): 361-366.
Rahalison, L., et al. “Screening for antifungal activity of Panamanian Plants.” Inst. J. Pharmacog. 1993; 31(1): 68-76.
Verpoorte, R., et al. “Medicinal plants of Surinam. IV. Antimicrobial activity of some medicinal plants.” J. Ethnopharmacol. 1987; 21(3): 315-318.
Sangre de Grado (Croton lechleri)
In 1994 phytochemicals were found in sangre de grado resin, including phenolic compounds, proanthocyanadins, and diterpenes, which showed potent antibacterial activity (against E. coli and Bacillus subtilis) as well as wound-healing properties. Another study documented sangre de grado's antioxidant effects and researchers in Canada documented its antifungal properties.
Pieters, L., et al. "Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton sp.) as an inhibitor of cell proliferation." J. Nat. Prod. 1993; 56(6): 899–906.
Chen, Z. P., et al. "Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon's blood." Planta Med. 1994; 60(6): 541–45.
Desmarchelier, C., et al. "Effects of sangre de drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals." J. Ethnopharmacol. 1997; 58: 103–8.
Macrae, W.D., et al. "Studies on the pharmacological activity of Amazonian Euphorbiaceae." J. Ethnopharmacol. 1988; 22(2): 143–72.
Pau d'Arco (Tabebuia impetiginosa)
Antimicrobial properties of many of pau d'arco's active phytochemicals were demonstrated in several clinical studies, in which they exhibited strong in vitro activity against bacteria, fungi, and yeast (including Candida, Aspergillus, Staphylococcus, Streptococcus, Helicobacter pylori, Brucella, tuberculosis, pneumonia, and dysentery). A water extract of pau d'arco was reported (in other in vitro clinical research) to have strong activity against 11 fungus and yeast strains.
Portillo, A., et. al. “Antifungal activity of Paraguayan plants used in traditional medicine.” J. Ethnopharmacol. 2001 Jun; 76(1):93-8.
Gershon, H., et al. “Fungitoxicity of 1,4-naphthoquinonoes to Candida albicans and Trichophyton mentagrophytes.” Can. J. Microbiol. 1975; 21: 1317-1321.
Binutu, O. A., et al. “Antimicrobial potentials of some plant species of the Bignoniaceae family.” Afr. J. Med. Med. Sci. 1994 Sep; 23(3): 269-73.
Guiraud, P., et al. “Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone.” Planta Med. 1994 Aug;60(4):373-4.
Anamu (Petiveria alliacea)
Anamu's antifungal properties were documented by one research group in 1991, and again by a separate research group in 2001. Its antimicrobial activity was further demonstrated by researchers from Guatemala and Austria who, in separate studies in 1998, confirmed its activity in vitro and in vivo studies against several strains of protozoa, bacteria, and fungi.
Benevides, P. J., et. al. “Antifungal polysulphides from Petiveria alliacea L.” Phytochemistry. 2001 Jul;57(5):743-7.
Caceres, A., et. al. “Plants used in Guatemala for the treatment of dermatophytic infections. 1. Screening for antimycotic activity of 44 plant extracts.” J. Ethnopharmacol. 1991; 31(3): 263-276.
Caceres, A., et. al. “Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plants.” J. Ethnopharmacol. 1998 Oct; 62(3):195-202.
Berger I., et al. "Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi." J. Ethnopharmacol. 1998 Sep; 62(2): 107-15.
Von Szczepanski, C., et al. "Isolation, structure elucidation and synthesis of antimicrobial substance from Petiveria alliacea." Arzneim-Forsch 1972; 22: 1975.
Copaiba Oil (Copaifera officinalis)
Copaiba resin is the highest known natural source of caryophyllene, comprising up to 480,000 parts per million. Caryophyllene is a well known plant chemical which has demonstrated pain-relieving properties, antifungal properties against nail fungus, as well as anti-inflammatory and gastroprotective properties in animal studies.
Yang, D., et al. "Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis." Mycopathologia 1999; 148(2): 79–82.
Paiva, L. A., et al. "Investigation on the wound healing activity of oleo-resin from Copaifera langsdorfii in rats." Phytother. Res. 2002; 16(8): 737-39.
Basile, A. C., et al. "Anti-inflammatory activity of oleoresin from Brazilian Copaifera." J. Ethnopharmacol. 1988; 22: 101-9.
Tincusi, B. M., et al. "Antimicrobial terpenoids from the oleoresin of the Peruvian medicinal plant Copaifera paupera." Planta Med. 2002; 68(9): 808-12.
Clavillia (Mirabilis jalapa)
Of particular interest to researchers studying clavillia is a group of amino acid-based proteins, called mirabilis antiviral proteins (MAPs). These chemicals have shown specific antiviral and antifungal actions. They are produced in the seeds, roots, and young shoots, and help the plant protect against various plant viruses and soil-borne fungi. In an in vitro laboratory study, a hot water extract of the flower, leaf, and root of clavillia demonstrated antifungal activity.
Caceres, A., et al. "Plants used in Guatemala for the treatment of dermatophytic infections. Screening for antimycotic activity of 44 plant extracts." J. Ethnophamacol. 1991; 31(3): 263-76.
Dimayuga, R. E.., et al. "Antimicrobial activity of medicinal plants from Baja California Sur (Mexico)." Pharmaceutical Biol. 1998; 36(1): 33-43.
Caceres, A., et al. "Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases." J. Ethnopharmacol. 1987; 20(3): 223-37.
Dhar, M. L., et al. "Screening of Indian plants for biological activity: Part I." Indian J. Exp. Biol. 1968; 6: 232-47.
Brazilian Peppertree (Schinus molle)
In laboratory tests, the essential oil (as well as leaf and bark extracts) has demonstrated potent antimicrobial properties. Brazilian peppertree has displayed good-to-very strong in vitro antifungal actions against numerous fungi, as well as Candida. One research group indicated that the antifungal action of the essential oil was more effective than the antifungal drug Multifungin®. Research publish in 2005 continues to document Brazilian peppertree's antifungal and anticandidal activities.
Schmourlo, G., et al. "Screening of antifungal agents using ethanol precipitation and bioautography of medicinal and food plants." J. Ethnopharmacol. 2005 Jan 15;96(3):563-8.
Dikshit, A. “Schinus molle: a new source of natural fungitoxicant.” Appl. Environ. Microbiol. 1986; 51(5), 1085-1088
Gundidza, M. “Antimicrobial activity of essential oil from Schinus molle Linn.” Central Africian J. Med. 1993; 39 11: 231-234.
Martinez, M. J., et al. "Screening of some Cuban medicinal plants for antimicrobial activity." J. Ethnopharmacol. 1996; 52(3): 171-74.
El-Keltawi, N., et al. "Antimicrobial activity of some Egyptian aromatic plants." Herba Pol. 1980; 26(4): 245-50.
Fedegoso (Cassia occidentalis)
Fedegoso has also been used for many types of bacterial, fungal, and parasitic infections for many years in the tropical countries where it grows. In vitro clinical research on fedegoso leaves over the years has reported active antibacterial, antifungal, antiparasitic, insecticidal, and antimalarial properties.
Qureshi, S., “In vitro evaluation of inhibitory nature of extracts of 18-plant species of Chindwara against 3-keratinophilic fungi.” Hindustan Antibiot. Bull. 1997 Feb-Nov; 39(1-4):56-60.
Caceres, A., et al. “Plants used in Guatemala for the treatment of dermatophytic infections. 2. Evaluation of antifungal activity of seven American plants.” J. Ethnopharmacol. 1993 Dec; 40(3):207-13.
Caceres, A., et al. “Plants used in Guatemala for the treatment of dermatophytic infections. 1. Screening for antimycotic activity of 44 plant extracts.” J. Ethnopharmacol. 1991 Mar; 31(3):263-76.
* The statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, mitigate or prevent any disease.
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