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N-TENSE TOPICAL 2 Fluid Ounces (60 ml)
N-TENSE combines the rainforest's most potent and powerful plants into one synergistic formula that is cytotoxic to cancer cells without toxicity to healthy cells. This proprietary and topical formula for the skin is similar to our popular N-Tense Capsules. These power plants have been independently documented around the world with active pharmacological actions against cancer,bacteria, virus, protozoa and inflammation.* This formula contains: graviola, mullaca, sangre de grado, vassourinha, copaiba oil, espinheira santa, mutamba, bitter melon, and cat's claw. For more information about these power plants of the rainforest, go to www.rain-tree.com's excellent plant database file.
Each rainforest botanical in N-Tense Topical has been sustainably harvested in the Amazon Rainforest. They are processed without chemicals or irraditation.
Documentation and Research*
A partial listing of published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research.
Graviola (Annona muricata)
Liaw, C. C., et al. “New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2002; 65(4): 470–75.
Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2001; 64(7): 925–31.
Zeng, B. B., et al. “Studies on mimicry of naturally occurring Annonaceous acetogenins: Non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells.” Chemistry. 2003 Jan 3; 9(1): 282-90.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102–6.
Gonzalez-Coloma, A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.” Z. Naturforsch [C]. 2002; 57(11-12): 1028-34.
Tormo, J. R., et al. “Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.” Chem. Biol. Interact. 1999 Nov 1; 122(3): 171-83.
Kim , G. S., et al. “Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. Phytochemistry. 1998 Sep; 49(2): 565-71.
Betancur-Galvis, L., et al. "Antitumor and antiviral activity of Colombian medicinal plant extracts." Mem Inst Oswaldo Cruz. 1999 Jul-Aug; 94(4): 531-5.
Mullaca (Physalis angulata)
Chiang, H., et al. “Antitumor agent, physalin F from Physalis angulata L.” Anticancer Res. 1992; 12(3): 837–43.
Ismail, N., et al. “A novel cytotoxic flavonoid glycoside from Physalis angulata.” Fitoterapia 2001 Aug. 72(6): 676–79.
Chiang, H. et al. “Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.” Anticancer Res. 1992; 12(4): 1155–62.
Kawai, M., et al. “Cytotoxic activity of physalins and related compounds against HeLa cells.” Pharmazie. 2002; 57(5): 348–50.
Sange de Grado (Croton lechleri)
Itokawa, H., et al. "A cytotoxic substance from sangre de grado." Chem. Pharm. Bull. (Tokyo) 1991; 39(4): 1041-42.
Pieters, L., et al. "Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton sp.) as an inhibitor of cell proliferation." J. Nat. Prod. 1993; 56(6): 899-906.
Chen, Z. P., et al. "Studies on the anti-tum our, anti-bacterial, and wound-healing properties of dragon's blood." Planta Med. 1994; 60(6): 541-45.
Vaisberg, A. J., et al. "Taspine is the cicatrizant principle in sangre de grado extracted from Croton lechleri." Planta Med. 1989; 55(2): 140-43.
Perdue, G. P., et al. "South Am erican plants II: Taspine isolation and anti-inflammatory activity." J. Pharm. Sci. 1979; 68(1): 124-26.
Copaiba Resin (Copaifera sp.)
Ohsaki, A., et al. "The isolation and in vivo potent antitumor activity of clerodane diterpenoids from the oleoresin of Brazilian medicinal plant Copaifera langsdorffii Desfon." Bioorg. Med. Chem. Lett. 1994; 4: 2889-92.
Costa-Lotufo, L. V., et al. "The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffi." Toxicon 2002; 40(8): 1231-34.
Basile, A. C., et al. "Anti-inflammatory activity of oleoresin from Brazilian Copaifera." J. Ethnopharmacol. 1988; 22: 101-9.
Paiva, L. A., et al. "Investigation on the wound healing activity of oleo-resin from Copaifera langsdorfii in rats." Phytother. Res. 2002; 16(8): 737-39.
Espinheira Santa (Maytenus ilicifolia)
Itokawa, H., et al. “Antitumor substances from South American plants.” Pharmacobio. Dyn. 1992; 15(1): S-2.
Arisawa, M., et al. “Cell growth inhibition of KB cells by plant extracts.” Natural Med. 1994; 48(4): 338–347.
Buffa Filho, W., et al. "Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography." Phytochem Anal. 2002 Mar-Apr; 13(2): 75-8.
Shirota, O., et al. “Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca.” J. Nat. Prod. 1994; 57(12): 1675–81.
Horn, R.C., et al. "Antimutagenic activity of extracts of natural substances in the Salmonella/microsome assay." Mutagenesis. 2003 Mar; 18(2): 113-8.
Ladino, C.A., et al. “Folate-maytansinoids: target-selective drugs of low molecular weight.” Int. J. Cancer. 1997 Dec 10; 73(6): 859-64.
Melo, A. M., et al. "First observations on the topical use of primin, plumbagin and maytenin in patients with skin cancer." Rev. Inst. Antibiot. 1974 Dec.
Chabner, B. A., et al., "Initial clinical trials of mayansine, an antitumor plant alkaloid." Cancer Treatment Reports 1978; (62): 429-33.
O'Connell, M. J., et al. "Phase II trial of maytansine in patients with advanced colorectal carcinoma." Cancer Treatment Reports 1978 (62); 1237-38.
Cabanillas, F., et al. "Phase I study of maytansine using a 3-day schedule." Cancer Treatment Reports 1976; (60): 1127-39.
Bitter Melon (Momordica charantia)
Claflin, A. J., et al. “Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).” Proc. Natl. Acad. Sci. 1978; 75(2): 989–93.
Terenzi, A., et al. “Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumor activity against CD30+ tumor cells in vitro and in SCID mice.” Br. J. Haematol. 1996; 92(4): 872–79.
Nagasawa, H., et al. “Effects of bitter melon (Momordica charantia) or ginger rhizome (Zingiber offifinale Rosc.) on spontaneous mammary tumorigenesis in SHN m ice.” Am. J. Clin. Med. 2002; 30(2–3): 195–205.
Pongnikorn, S., et al. “Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy.” J. Med. Assoc.Thai. 2003; 86(1): 61-8.
Vassourinha (Scoparia dulcis)
Nishino, H. “Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L.” Oncology 1993; 50(2): 100–3.
Hayashi T, A cytotoxic flavone from Scoparia dulcis L. Chem Pharm Bull (Tokyo). 1988 Dec; 36(12): 4849-51.
Noda, Y., et al. “Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media; possibility of a new mode of cell killing.” Chem. Pharm. Bull. 1997; 45(10): 1665–70.
Zuco, V., et al. “Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.” Cancer Lett. 2002; 175(1): 17–25.
Ahsan, M., et al. “Cytotoxic diterpenes from Scoparia dulcis.” J. Nat. Prod. 2003; 66(7): 958-61.
Mutamba (Guazuma ulmifolia)
Nascimento, S. C., et al. “Antimicrobial and cytotoxic activities in plants from Pernambuco, Brazil.” Fitoterapia 1990; 61(4): 353–55.
Kashiwada, Y., et al. “Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.” J. Nat. Prod. 1992; 55(8): 1033–43.
Navarro, M.C., et al. "Antibacterial, antiprotozoal and antioxidant activity of five plants used in Izabal for infectious diseases." Phytother Res. 2003; 17(4):325-9.
Caballero-George, C., et al. "In vitro inhibition of [3H]-angiotensin II binding on the human AT1 receptor by proanthocyanidins from Guazuma ulmifolia bark." Planta Med. 2002 Dec; 68(12): 1066-71.
Ito, H., et al. “Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.” J. Agric. Food Chem. 2002; 50(8): 2400–3.
Cat’s Claw (Uncaria tomentosa)
Sheng, Y., et al. “Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.” Anticancer Res. 1998 Sep-Oct;18(5A): 3363-8.
Akesson, C., et al. "An extract of Uncaria tomentosa inhibiting cell division and NF-kappaB activity without inducing cell death." Int. Immunopharmacol. 2003 Dec; 3(13-14): 1889-900.
Sheng, Y., et al. "Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa." Phytomedicine. 2000 Apr; 7(2): 137-43.
Riva, L., et al. "The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line." Anticancer Res. 2001 Jul-Aug; 21(4A): 2457-61.
Sheng, Y., et al. "DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study." Phytomedicine. 2001 Jul; 8(4): 275-82.
Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa.” J. Ethnopharmacol. 1999 Feb;64(2):109-15.
* The statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to treat, cure, mitigate or prevent any disease.
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